Enigmatic insight into collagen

Crystallographic Insight into Collagen Recognition by Discoidin Domain Receptor 2

The discoidin domain receptors, DDR1 and DDR2, are widely expressed receptor tyrosine kinases that are activated by triple-helical collagen. They control important aspects of cell behavior and are dysregulated in several human diseases. The major DDR2-binding site in collagens I-III is a GVMGFO motif (O is hydroxyproline) that also binds the matricellular protein SPARC. We have determined the c...

Mitophagy: New Insight into the Cardiovascular Aging  

New Insight into the Relation between Adiponectin and Diabetes

Diabetes mellitus is a group of metabolic diseases. Insulin resistance is defined as a state that needs more insulin to get the biological effects achieved by a lower amount of insulin in the normal state. Several molecules which are secreted through adipocytes have been involved in insulin resistance and type 2 diabetes mellitus. Adiponectin as a 244 amino acid protein is exclusively expressed...

Newt insight into regeneration

1 0. 10 83 /j cb. 17 23 it i3 j cb 17 23 it i3 Nicole [email protected] ewt ins ight into regenerat ion L imb regeneration, as seen in amphibians, might not be as far from humanly possible as once thought. On page 433 , Morrison et al. show that the regeneration of newt limbs hinges on the activation of muscle satellite cells—t...

New insight into superconductivity

NOVEMBER 2008 | VOLUME 11 | NUMBER 11 13 The physics of high-temperature cuprate superconductors in the overdoped regime, where superconductivity is suppressed, is something of a mystery. But first-principle calculations by researchers in the US and Switzerland appear to confirm a recent suggestion that ferromagnetism can destroy superconductivity at high doping levels [B. Barbiellini and T. Ja...